Effect of Hongjin Xiaojie capsule,goserelin combined with laparoscopic myomectomy in the treatment of uterine fibroids and its influence on neovascularization
Objective To analyze the effect of Hongjin Xiaojie capsule,goserelin combined with laparoscopic myomectomy in the treatment of uterine fibroids and its influence on neovascularization.Methods A total of 80 patients with uterine fibroids admitted in our hospital from January 2019 to February 2022 were selected as the research objects.The patients were divided into control group and observation group by random number table method,with 40 cases in each group.Both groups underwent laparoscopic myomectomy.The control group was treated with goserelin after operation,and the observation group was treated with Hongjin Xiaojie capsule on the basis of the control group.The therapeutic effects of the two groups were compared.Results After 6 months of treatment,the uterine artery resistance index(RI)and pulsatility index(PI)in the observation group were higher than those in the control group,and the peak systolic velocity(PSV)was lower than that in the control group(P<0.05).After 6 months of treatment,the levels of vascular endothelial growth factor(VEGF),microvessel density(MVD)and epidermal growth factor(EGF)in the observation group were lower than those in the control group(P<0.05).After 6 months of treatment,the levels of estradiol(E2),prolactin(PRL),follicle stimulating hormone(FSH)and luteinizing hormone(LH)in the observation group were lower than those in the control group(P<0.05).The total incidence of complications and recurrence rate of uterine fibroids in the observation group were lower than those in the control group(P<0.05).Conclusion Hongjin Xiaojie capsule,goserelin combined with laparoscopic myomectomy in the treatment of uterine fibroids can improve the neovascularization indexes,reduce the incidence of complications and the recurrence rate of uterine fibroids,and help to restore uterine microcirculation and ovarian function,which is worthy of promotion in clinic.
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