Objective To investigate the effect of hepatitis C virus(HCV)infection on postoperative adjuvant chemotherapy in patients with gastrointestinal cancer.Methods The patients with gastrointestinal cancer and HCV infection who needed immediate postoperative adjuvant chemotherapy were retrospectively selected as study group(29 cases),and the patients with gastrointestinal cancer who were HCV negative received postoperative adjuvant chemotherapy were selected as control group(59 cases).The general information and clinical characteristics of the two groups were compared,and the effect of HCV infection on postoperative adjuvant chemotherapy in patients with gastrointestinal cancer was analyzed.Results The baseline alanine transaminase(ALT)level of the study group was higher than that of the control group,and the increase of ALT level after chemotherapy was more significant(P<0.05).The total incidences of severe adverse events(SAEs)and adverse events(AEs)in the study group were higher than those in the control group(P<0.05).The probability of chemotherapy delay and chemotherapy drug reduction in the study group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The patients with HCV-positive gastrointestinal cancer are more likely to have adverse reactions during postoperative adjuvant chemotherapy;HCV pasitive hinders the successful completion of chemotherapy and should be closely monitored.
关键词
丙型肝炎病毒/胃肠道肿瘤/化疗/直接抗病毒药物/药物相互作用/谷丙转氨酶/严重不良事件
Key words
hepatitis C virus/gastrointestinal cancer/chemotherapy/direct antiviral drug/drug interaction/alanine transaminase/severe adverse event
维普
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