Effect of interventional therapy through popliteal vein approach combined with rivaroxaban on deep venous thrombosis of lower extremity in hemodialysis and its influences on coagulation and fibrinolysis functions
Objective To investigate the effect of interventional therapy through popliteal vein approach combined with rivaroxaban on deep venous thrombosis of lower extremity in hemodialysis and its influences on coagulation and fibrinolysis functions.Methods From January 2018 to January 2022,60 hemodialysis patients with deep venous thrombosis of lower extremity undergoing indwelling femoral vein catheter were selected as the research objects.According to the difference of treatment methods,the patients were divided into control group(30 cases,rivaroxaban treatment)and observation group(30 cases,interventional therapy through popliteal vein approach combined with rivaroxaban treatment).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the circumference differences of the thigh and calf in the observation group were lower than those in the control group(P<0.05).After treatment,the prothrombin time(PT)and activated partial thromboplastin time(APTT)in the observation group were longer than those in the control group,and the levels of fibrinogen(FIB),thrombomodulin(TM),tissue plasminogen activator-plasminogen activator inhibitor-1 complex(t-PAIC)and plasmin antiplasmin complex(PIC)were lower than those in the control group(P<0.05).Conclusion Interventional therapy through popliteal vein approach combined with rivaroxaban on deep venous thrombosis of lower extremity in hemodialysis can improve the therapeutic effect,reduce the swelling of lower extremities,and promote the improvement of coagulation and fibrinolysis functions,which is worthy of promotion.
interventional therapy through popliteal vein approachrivaroxabanhemodialysisdeep venous thrombosis of lower extremitycoagulation functionfibrinolysis function
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