Effect of early combined application of exogenous PS and iNO in the treatment of PPHN
Objective To investigate the effect of early combined application of exogenous pulmonary surfactant(PS)and inhaled nitric oxide(iNO)in the treatment of persistent pulmonary hypertension of the newborn(PPHN)in neonates.Methods A total of 100 cases of PPHN admitted from January 1,2019 to December 31,2021 were selected as the research objects and divided into control group and observation group according to the random number table method,with 50 cases in each group.The control group was treated with iNO + placebo(air),and the observation group was treated with iNO + exogenous PS.The therapeutic effects of the two groups were compared.Results Before treatment,there were no significant differences in pulmonary artery systolic pressure(PASP),partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2),pH and oxygenation index(OI)between the two groups(P>0.05);after 24,48 h of treatment,the PASP,PaCO2 and OI of the two groups decreased,PaO2 and pH increased,those in the observation group were better than the control group,and the differences were statistically significant(P<0.05).The cure rate of the observation group was significantly higher than that of the control group,the rate of application of extracorporeal membrane oxygenation(ECMO)and death were lower than those of the control group,the ventilator use time and hospitalization time were shorter than those of the control group,and the differences were statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Early combined application of exogenous PS and iNO can significantly improve oxygenation,reduce PASP,reduce ventilator use time,hospitalization time,ECMO demand and mortality in children with PPHN,which is worthy of clinical promotion and application.
pulmonary surfactantinhaled nitric oxidepersistent pulmonary hypertension of the newborn
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