Effect of modified Zhizi Chi decoction combined with western medicine on insomnia after corona virus disease 2019 infection
Objective To observe the effect of modified Zhizi Chi decoction combined with western medicine on insomnia after corona virus disease 2019 infection.Methods Sixty patients with insomnia after corona virus disease 2019 infection who were admitted in the encephalopathy center of the First Affiliated Hospital of Anhui University of Chinese Medicine from October 2022 to June 2023 were selected as the research objects,and the patients were divided into control group and treatment group according to random number table method,with 30 cases in each group.The control group was given dexzopiclone 3 mg orally before going to bed,the treatment group was given modified Zhizi Chi decoction on the basis of the control group,and the course of treatment was 2 weeks.The therapeutic effect,sleep quality,insomnia severity and treatment safety were compared between the two groups.Results At the time of drug withdrawal and 2 weeks after drug withdrawal,the total effective rate of treatment in the treatment group was slightly higher than that in the control group,but the difference was not statistically significant(P>0.05).Before treatment,there were no significant differences in Pittsburgh Sleep Quality Index(PSQI)and Insomnia Severity Index(ISI)scores between the two groups(P>0.05);at 2 weeks after drug withdrawal,the PSQI and ISI scores of the two groups were lower than those before treatment,and those in the treatment group were lower than the control group,the differences were statistically significant(P<0.05);at the time of drug withdrawal,the ISI score of the two groups was lower than that before treatment,and that in the treatment group was lower than the control group,the difference was statistically significant(P<0.05);at 2 weeks after drug withdrawal,the ISI score of the control group was higher than that at the time of drug withdrawal,and the difference was statistically significant(P<0.05);there was no significant difference in ISI score between the treatment group at the time of drug withdrawal and 2 weeks after drug withdrawal(P>0.05).During the treatment,there were occasional dizziness or headache symptoms in both groups,and 1 patient in the treatment group had diarrhea symptoms during the treatment.There was no obvious abnormality in liver and kidney function during follow-up in both groups.Conclusion The modified Zhizi Chi decoction combined with western medicine in the treatment of insomnia after corona virus disease 2019 infection has good efficacy and safety.
Zhizi Chi decoctionwestern medicinecorona virus disease 2019 infectioninsomniasleep qualitysafety
万方数据
维普
