首页|国产PD-1抑制剂在妇科肿瘤中的研究现状

国产PD-1抑制剂在妇科肿瘤中的研究现状

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妇科肿瘤是威胁女性生命的恶性疾病,其中最常见的是宫颈癌、卵巢癌和子宫内膜癌,其发病率逐年上升。妇科肿瘤治疗的基础是手术、放疗和化疗的联合治疗,但综合治疗后仍有患者因耐药或复发而死亡。目前PD-1/PD-L1免疫抑制剂应用于妇科恶性肿瘤已初见成效,有望成为未来最有潜力攻克妇科恶性肿瘤的药物。本文主要对当前国产PD-1 免疫治疗在妇科肿瘤中的临床研究结果作一综述,以期概括国内妇科肿瘤免疫治疗思路,寻找合适的免疫治疗策略,延长晚期患者的生存期。
Research status of domestic PD-1 inhibitors in gynecological tumors
Gynecological tumors are malignant diseases that threaten the lives of women.The most common are cervical cancer,ovarian cancer and endometrial cancer,and their incidence is increasing year by year.The treatment of gynecological tumors is based on the combination of surgery,radiotherapy and chemotherapy,but there are still patients who die due to drug resistance or recurrence after comprehensive treatment.At present,PD-1/PD-L1 immunosuppressive agents have achieved initial results in the treatment of gynecological malignant tumors,and are expected to become the most potential drugs to overcome gynecological malignant tumors in the future.This article reviews the current clinical research results of domestic PD-1 immunotherapy in gynecological tumors,in order to summarize the domestic immunotherapy ideas for gynecological tumors,find appropriate immunotherapy strategies,and prolong the survival of advanced patients.

gynecological tumordomestic PD-1 inhibitorimmunotherapy

卓青婵、朱敏莹、左瑜芳、官成浓

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广东医科大学,广东 湛江,524001

广东医科大学附属医院肿瘤中心,广东 湛江,524001

妇科肿瘤 国产PD-1抑制剂 免疫治疗

2021年度广东省医学科研基金立项项目

B2021114

2024

临床医学研究与实践

临床医学研究与实践

ISSN:
年,卷(期):2024.9(8)
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