Investigation of Clostridioides difficile infection in patients with diarrhea
Objective To understand the situation of Clostridioides difficile infection(CDI)in hospitalized diarrhea patients in Binzhou Central Hospital,so as to provide effective infection control measures for clinical practice.Methods A total of 94 patients with diarrhea who were hospitalized in Binzhou Central Hospital from September 2019 to May 2022 were selected as the research objects.The DNA of Clostridioides difficile(CD)was detected by GeneXpert method,and its occurrence under different clinical conditions was analyzed.Results Of the 94 patients,56 were CD-positive,with a positive rate of 59.6%,including 33 males(58.9%)and 23 females(41.1%);there were 11 cases(19.6%)in the age group of 19-＜60 years old and 45 cases(80.4%)in the age group of 60-90 years old;there were 20 cases(35.7%)with hospitalization time＜10 d and 36 cases(64.3%)with hospitalization time≥10 d;clinical diagnosis of tuberculosis in 40 cases(71.4%),non-tuberculosis in 16 cases(28.6%);there were 56 cases(100.0%)using antibiotics,and 0 cases without antibiotics.There were no significant differences in gender,age and hospitalization time between CD-positive and CD-negative patients(P＞0.05);there were statistically significant differences in clinical diagnosis and antibiotic use between CD-positive and CD-negative patients(P＜0.05).Among the 56 patients with CD-positive,49 case were type 027-positive and 7 cases were type 027-negative.Among the 027-positive cases,27 cases(55.1%)were males,and 22 cases(44.9%)were females;there were 7 cases(14.3%)in the age group of 19-＜60 years old,and 42 cases(85.7%)in the age group of 60-90 years old;there were 16 cases(32.7%)with hospitalization time＜10 d and 33 cases(67.3%)with hospitalization time≥10 d;clinical diagnosis of tuberculosis in 40 cases(81.6%),non-tuberculosis in 9 cases(18.4%).There were no significant differences in gender and hospitalization time between 027-positive and 027-negative patients(P＞0.05);there were statistically significant differences in age and clinical diagnosis between 027-positive and 027-negative patients(P＜0.05).Conclusion The detection of CD by GeneXpert method has the advantages of fast,high sensitivity and high specificity,which can quickly help the clinical diagnosis of CDI.The gender and age of diarrhea patients are not significantly correlated with CDI,while tuberculosis and the use of antibiotics are the related factors of CDI.CDI is prone to occur in patients with diarrhea and tuberculosis,and it is a high-yield toxin type 027.Therefore,hospital infection control should be strengthened for patients with diarrhea and tuberculosis.
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