Objective To compare the effects of serratus anterior plane block(SAPB)and patient controlled intravenous analgesia(PCIA)on postoperative analgesia,pain mediators,hemodynamics and inflammatory mediators after radical gastrectomy.Methods A total of 72 patients who underwent radical gastrectomy from May 2021 to May 2023 were selected as the study objects.The patients were divided into study group(n=37)and control group(n=35)according to different analgesic methods.The two groups were given same surgical anesthesia.After operation,the study group was given SAPB,and the control group was given PCIA.The analgesic effects of the two groups were compared.Results At 4 and 24 h after operation,the Visual Analogue Scale(VAS)score of the study group was lower than that of the control group,and the Ramsay score was higher than that of the control group(P＜0.05).At 4 h after operation,the levels of 5-hydroxytryptamine(5-HT)and prostaglandin E2(PGE2)in the two groups increased,but those in the study group were significantly lower than the control group(P＜0.05).At 4 h after operation,the heart rate(HR)and systolic blood pressure(SBP)of the two groups increased,but those in the study group were lower than the control group(P＜0.05).At 4 h after operation,the levels of interleukin-6(IL-6)and interleukin-1β(IL-1β)in the two groups increased,but those in the study group were significantly lower than the control group(P＜0.05).The total incidence of adverse reactions in the study group was significantly lower than that in the control group(P＜0.05).Conclusion SAPB is superior to PCIA in analgesia and sedation after radical gastrectomy.It can inhibit the production of pain mediators,stabilize hemodynamics,and reduce inflammatory response,which is worthy of promotion.
维普
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