Value of heparin-binding protein in the early diagnosis and prognosis evaluation of sepsis
Objective To investigate the value of heparin-binding protein(HBP)in the early diagnosis and prognosis evaluation of sepsis.Methods A total of 182 patients with sepsis admitted from January 2019 to January 2022 were selected.According to the guidelines of sepsis,the patients were divided into sepsis non-shock group(114 cases)and sepsis shock group(68 cases);according to the clinical prognosis,the patients were divided into sepsis survival group(142 cases)and sepsis death group(40 cases).In addition,80 healthy subjects in the same period were selected as healthy group.The levels of HBP,procalcitonin(PCT),C-reactive protein(CRP)and white blood cell(WBC)within 24 h after admission were compared among all groups,and the value of the above indexes in early diagnosis and prognosis evaluation of sepsis was analyzed by receiver operating characteristic(ROC)curve.Results The levels of HBP,PCT,CRP and WBC in the sepsis shock group and the sepsis non-shock group were higher than those in the healthy group(P＜0.05);the levels of HBP,PCT and CRP in the sepsis shock group were higher than those in the sepsis non-shock group(P＜0.05);there was no significant difference in WBC between the sepsis non-shock group and the sepsis shock group(P＞0.05).HBP,PCT,CRP and WBC all had certain diagnostic value in sepsis(P＜0.05),and HBP had the highest diagnostic value[area under the curve(AUC)=0.947].When the cut-off value of HBP was 10.50 ng/mL,the sensitivity was 80.22%,and the specificity was 92.50%.The levels of HBP,PCT,CRP and WBC in the sepsis death group were higher than those in the sepsis survival group(P＜0.05).Logistic regression analysis results showed that HBP and PCT were the risk factors affecting the prognosis of sepsis patients(P＜0.05).ROC curve analysis results showed that the AUC of HBP and PCT were 0.724 and 0.862 respectively,and the AUC of combined detection of the two was 0.877.Conclusion HBP has good clinical val ue in the diagnosis of sepsis and is an independent risk factor for sepsis prognosis.Combined with PCT detection can better evaluate the prognosis of patients with sepsis.
万方数据
维普
