首页|以癫痫发作为首发表现的甲状旁腺功能减退症患者1例报道并文献复习

以癫痫发作为首发表现的甲状旁腺功能减退症患者1例报道并文献复习

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甲状旁腺功能减退症(HP)是指甲状旁腺激素(PTH)分泌过少和/或效应不足而引起低钙血症、高磷血症、软组织异位钙化和神经肌肉兴奋性增高等为临床特征的一组临床综合征。近期我院收治了 1 例以反复癫痫发作为表现的HP患者,该患者 10 余年前反复出现发作性意识丧失、双眼凝视、牙关紧闭、四肢抽搐,每次发作持续约数分钟,上述症状可自行好转,醒后不能回忆发病过程,就诊于外院,诊断为癫痫予以规律抗癫痫药物治疗,治疗期间上述症状仍反复发作,起初发病频率低,约每年发作 1 次,近 2年来发作频率增加,平均 2~3 月发作 1 次。入院前 3d因受凉后再次出现意识丧失、双眼凝视、牙关紧闭、四肢抽搐,发作 1 次,持续约 10 余分钟后自行苏醒,醒后出现头晕、肢体乏力,伴精神差、纳差,有咳嗽、咳痰等临床表现,就诊于我科。现对这一病例的发病情况、诊疗经过进行总结,并复习相关文献,以期加深临床医师对HP相关癫痫的认识。
A case report and literature review of a patient with hypoparathyroidism with epilepsy as the first manifestation
Hypoparathyroidism(HP)is a clinical syndrome characterized by hypocalcemia,hyperphosphatemia,soft tissue ectopic calcification,and increased neuromuscular excitability due to insufficient secretion and/or insufficie nt effect of parathyroid hormone(PTH).Recently,our hospital admitted a patient with recurrent epilepsy as a manifestation of HP,and the patient had recurrent episodic loss of consciousness,binocular gaze,closed teeth,and convulsion of the limbs more than 10 years ago.Each episode lasted for about a few minutes,and the above symptoms could improve on their own.After waking up,the patient could not recall the course of the disease.The patient were diagnosed with epilepsy at an external hospital and treated with regular antiepileptic drugs.During the treatment,the above symptoms still recurred,with a low initial frequency of onset,about once a year.In the past two years,the frequency of seizures has increased,with an average of once every 2 to 3 months.Three days before admission,there was a recurrence of consciousness loss,binocular gaze,closed teeth,and convulsion of the limbs due to catching a cold.The seizures occurred once and lasted for about 10 minutes before awakening on their own.After waking up,they experienced dizziness,limb weakness,accompanied by poor mental state,poor appetite,cough,sputum,and other clinical manifestations,and the patient was treated at our department.We summarize the incidence,diagnosis and treatment process of this case,and review relevant literature in order to deepen the understanding of HP related epilepsy among clinical physicians.

hypoparathyroidismepilepsyhypocalcemia

熊倩、王倩、张琴彬、张国华、刘安祥

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贵州茅台医院神经内科,贵州 仁怀,564500

甲状旁腺功能减退症 癫痫 低钙血症

2024

临床医学研究与实践

临床医学研究与实践

ISSN:
年,卷(期):2024.9(10)
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