Objective To explore the independent risk factors of clinically significant prostate cancer(csPCa)for patients with prostate imaing-reporting and data system(PI-RADS)scores 3.Methods From January 2018 to June 2022,118 patients with prostate system puncture PI-RADS scores 3 in the urology department of Shaanxi Provincial People's Hospital were selected as the research objects.Logistic regression analysis was used to identify the independent risk factors of csPCa,and the accuracy of free prostate-specific antigen/total prostate-specific antigen(fPSA/tPSA),prostate-specific antigen density(PSAD)and digital rectal examination alone and in combination for diagnosing csPCa was evaluated by receiver operating characteristic curve(ROC)and area under curve(AUC).Results Of the 118 patients,29 cases(24.58%)were diagnosed with csPCa and 89 cases(75.42%)were diagnosed with non-csPCa.Multivariate Logistic regression analysis showed that fPSA/tPSA≤0.16,PSAD≥0.20 ng/mL2 and abnormal digital rectal examination were independent risk factors for csPCa(P<0.05).The AUC values of fPSA/tPSA,PSAD and digital rectal examination in the diagnosis of csPCa were 0.71,0.80 and 0.74,respectively,and the AUC value after combined application was 0.91.Conclusion Before biopsy fPSA/tPSA≤0.16,PSAD≥0.20 ng/mL2 and abnormal digital rectal examination are independent risk factors for csPCa,and the combined application can significantly improve the diagnostic accuracy of csPCa,which is worthy of clinical promotion and application.
关键词
临床有意义前列腺癌/前列腺影像报告与数据系统评分/危险因素/前列腺穿刺/前列腺特异性抗原密度
Key words
clinically significant prostate cancer/prostate imaing-reporting and data system score/risk factor/prostate biopsy/prostate-specific antigen density
维普
万方数据