Objective To exp lore the applicat ion value of quantitative detection of serum procalcitonin(PCT)in pathogen distribution of bloodstream infection in patients with sepsis,and to provide a basis for clinical rational use of PCT index to predict the results of pathogenic bacteria of bloodstream infection in patients with sepsis.Methods A total of 200 sepsis patients with positive blood culture and PCT detection admitted from January 2016 to June 2021 were selected as the research objects.According to the infection of Gram-negative bacteria and Gram-positive bacteria,the patients were divided into G-group(165 cases)and G+ group(35 cases).The detection of pathogens were analyzed and serum PCT level of the two groups were compared,and the optimal critical value of PCT was analyzed by receiver operating characteristic(ROC)curve.Results A total of 200 strains of pathogenic bacteria were isolated,165 strains of Gram-negative bacteria,accounted for 82.5%,and 35 strains of Gram-positive bacteria,accounted for 17.5%.The serum PCT level in the G-group was higher than that in the G+ group,and the difference was statistically significant(P<0.05).The results of ROC curve showed that the area under the curve was 0.674 and the 95%confidence interval was 0.564-0.783;when the Youden index was 0.300,the optimal critical value was 16.65 ng/mL,the sensitivity was 0.706,and the specificity was 0.594.Conclusion PCT has certain application value in pathogen distribution of bloodstream infection in patients with sepsis.It can provide a basis for rational drug use in patients with suspected sepsis in the early stage.It can be combined with blood culture to reduce the risk of anti-infection failure in patients with sepsis and improve the effective rate of treatment.
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