Study of application value of procalcitonin in pathogen distribution of bloodstream infection in patients with sepsis
Objective To exp lore the applicat ion value of quantitative detection of serum procalcitonin(PCT)in pathogen distribution of bloodstream infection in patients with sepsis,and to provide a basis for clinical rational use of PCT index to predict the results of pathogenic bacteria of bloodstream infection in patients with sepsis.Methods A total of 200 sepsis patients with positive blood culture and PCT detection admitted from January 2016 to June 2021 were selected as the research objects.According to the infection of Gram-negative bacteria and Gram-positive bacteria,the patients were divided into G-group(165 cases)and G+ group(35 cases).The detection of pathogens were analyzed and serum PCT level of the two groups were compared,and the optimal critical value of PCT was analyzed by receiver operating characteristic(ROC)curve.Results A total of 200 strains of pathogenic bacteria were isolated,165 strains of Gram-negative bacteria,accounted for 82.5%,and 35 strains of Gram-positive bacteria,accounted for 17.5%.The serum PCT level in the G-group was higher than that in the G+ group,and the difference was statistically significant(P<0.05).The results of ROC curve showed that the area under the curve was 0.674 and the 95%confidence interval was 0.564-0.783;when the Youden index was 0.300,the optimal critical value was 16.65 ng/mL,the sensitivity was 0.706,and the specificity was 0.594.Conclusion PCT has certain application value in pathogen distribution of bloodstream infection in patients with sepsis.It can provide a basis for rational drug use in patients with suspected sepsis in the early stage.It can be combined with blood culture to reduce the risk of anti-infection failure in patients with sepsis and improve the effective rate of treatment.
万方数据
维普
