Effect of salviae miltiorrhizae and ligustrazine hydrochloride injection combined with argatroban and alteplase intravenous thrombolysis in the treatment of acute cerebral infarction and its influences on platelet factor and nerve factor levels
Objective To investigate the effect of salviae miltiorrhizae and ligustrazine hydrochloride injection combined with argatroban and alteplase intravenous thrombolysis in the treatment of acute cerebral infarction and its influences on platelet factor and nerve factor levels.Methods A total of 100 patients with acute cerebral infarction who were admitted from January 2021 to December 2022 were selected as the research objects.According to different treatment schemes,the patients were divided into control group and observation group,with 50 cases in each group.The control group was treated with argatroban and alteplase intravenous thrombolysis,and the observation group was treated with salviae miltiorrhizae and ligustrazine hydrochloride injection on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of platelet-activating factor(PAF),granule membrane protein-140(GMP-140),β-thromboglobulin(β-TG)and platelet factor 4(PF4)in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of neuron-specific enolase(NSE)and glial fibrillary acidic protein(GFAP)in the observation group were lower than those in the control group,and the levels of nerve growth factor(NGF)and brain-derived neurotrophic factor(BDNF)were higher than those in the control group(P<0.05).Conclusion Salviae miltiorrhizae and ligustrazine hydrochloride injection combined with argatroban and alteplase intravenous thrombolysis can regulate the levels of platelet factor and nerve factor in patients with acute cerebral infarction,promote the recovery of nerve function,and have a significant effect,which is worthy of promotion.
salviae miltiorrhizae and ligustrazine hydrochloride injectionargatrobanalteplaseintravenous thrombolysisacute cerebral infarction
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