Value of serum SAA,ADP,CysC,HCY and SIRI in the early diagnosis of diabetic kidney disease
Objective To explore the value of serum amyloid A(SAA),adiponectin(ADP),cystatin C(CysC),homocysteine(HCY)and system inflammation response index(SIRI)in the early diagnosis of diabetic kidney disease(DKD).Methods A total of 167 patients with type 2 diabetes mellitus(T2DM)admitted from October 2022 to March 2023 were selected as the study objects.According to the occurrence of DKD,the patients were divided into DKD group(n=87)and non-DKD group(n=80);in addition,43 healthy subjects were randomly selected as healthy control group.SAA,ADP,CysC,HCY levels and SIRI were compared among the three groups;Spearman method was used to analyze the correlation between each index and estimated glomerular filtration rate(eGFR);binary Logistic regression was used to analyze the influencing factors of DKD;the receiver operator characteristic(ROC)curve was drawn to analyze the diagnostic value of SAA,ADP,CysC,SIRI alone and combined detection for DKD.Results The levels of SAA,ADP,CysC,HCY and SIRI in the DKD group were significantly higher than those in the non-DKD group and the healthy control group(P<0.05);the levels of ADP and HCY in the non-DKD group were lower than those in the healthy control group,and SIRI was higher than that in the healthy control group(P<0.05).The levels of CysC and HCY were negatively correlated with eGFR based on serum creatinine(Scr)(P<0.05);the levels of SAA,ADP,HCY and SIRI were negatively correlated with CysC-based eGFR(P<0.05).Binary Logistic regression analysis results showed that SAA,ADP,CysC and SIRI were independent risk factors for DKD(P<0.05).The area under curve(AUC)of combined detection of SAA,ADP,CysC and SIRI in the diagnosis of DKD was 0.964,and the sensitivity and specificity were 90.80%and 96.25%,respectively.Conclusion HCY has auxiliary diagnostic value for DKD;the combined detection of SAA,ADP,CysC and SIRI can effectively improve the sensitivity and specificity of early diagnosis of DKD,and has important clinical application value.
万方数据
维普
