Application of continuous hemofiltration combined with bedside hemoperfusion in emergency treatment of patients with acute organophosphorus poisoning
Objective To explore the application of continuous hemofiltration combined with bedside hemoperfusion in emergency treatment of patients with acute organophosphorus poisoning.Methods A retrospective analysis of 106 patients with acute organophosphorus poisoning admitted in the emergency department of our hospital from April 2020 to April 2023 were divided into control group(n=56)and observation group(n=50)according to different first aid methods.The control group was given bedside hemoperfusion therapy,and the observation group was given continuous hemofiltration therapy on the basis of the control group.The first aid effects of the two groups were compared.Results The dosage of atropine in the observation group was significantly less than that in the control group,and the recovery time of cholinesterase(ChE)and hospitalization time were significantly shorter than those in the control group(P<0.05).After treatment,the levels of interlcukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),alanine aminotransferase(ALT),creatine kinase(CK)and creatine kinase isoenzyme MB(CK-MB)in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion Continuous hemofiltration combined with bedside hemoperfusion can accelerate the recovery of patients with acute organophosphorus poisoning and regulate the levels of inflammatory factors and serum indicators.
万方数据
维普
