Clinical effect of aminophylline combined with terbutaline in the treatment of patients with stable chronic obstructive pulmonary disease and its influences on serum PCT and TNF-α levels
Objective To investigate the clinical effect of aminophylline combined with terbutaline in the treatment of stable chronic obstructive pulmonary disease(COPD).Methods A total of 80 patients with stable COPD admitted from January 2020 to December 2021 were selected as the research objects.According to the parity of admission number,the patients were divided into control group and observation group,with 40 cases in each group.The control group was given conventional symptomatic and terbutaline treatment,and the observation group was treated with aminophylline on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in one second(FEV1),maximum ventilation volume(MVV)and peak expiratory flow rate(PEF)in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group,and the level of interleukin-10(IL-10)was higher than that in the control group(P<0.05).After treatment,the diaphragm thickness,diaphragm activity and oxygenation index of the observation group were higher than those of the control group,and the arterial carbon dioxide partial pressure(PaCO2)and Chronic Obstructive Pulmonary Disease Assessment Test(CAT)score were lower than those of the control group(P<0.05).Conclusion The aminophylline combined with terbutaline in the treatment of stable COPD has ideal clinical effect.
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