Effect of adenosylmethionine succinate combined with ursodeoxycholic acid in the treatment of primary biliary cholangitis and its influences on oxidative stress indexes
Objective To study the effect of adenosylmethionine succinate combined with ursodeoxycholic acid in the treatment of primary biliary cholangitis(PBC)and its influences on oxidative stress indexes.Methods A total of 100 patients with PBC who were treated in our hospital from May 2017 to May 2022 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 50 cases in each group.The control group was treated with ursodeoxycholic acid,and the observation group was treated with adenosylmethionine succinate combined with ursodeoxycholic acid.The liver function indexes,inflammation and oxidative stress indexes,clinical efficacy and adverse reactions were compared between the two groups.Results After treatment,the levels of total bilirubin(TBiL),total bile acid(TBA),alanine amiotransferase(ALT),alkaline phosphatase(ALP)and aspartate aminotransferase(AST)in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-12(IL-12),phospholipid transfer protein(PLTP)and malondialdehyde(MDA)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The adenosylmethionine succinate combined with ursodeoxycholic acid in the treatment of PBC has ideal effect,which can significantly improve liver function and inhibit oxidative stress.
adenosylmethionine succinateursodeoxycholic acidprimary biliary cholangitisoxidative stress index
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维普
