Effect of Huangqi granule combined with minoxidil on seborrheic alopecia and its influences on growth factors levels
Objective To investigate the effect of Huangqi granule combined with minoxidil on seborrheic alopecia and its influences on growth factors levels.Methods A total of 120 patients with seborrheic alopecia admitted from January 2019 to January 2022 were selected and divided into control group and observation group by random number table method,with 60 cases in each group.The control group was treated with minoxidil,and the observation group was treated with Huangqi granules on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).Before treatment,there were no significant differences in the levels of estradiol(E2)and testosterone(T)between the two groups(P>0.05);after treatment,the E2 level of the observation group was higher than that of the control group,and the T level was lower than that of the control group(P<0.05).Before treatment,there were no significant differences in the levels of vascular endothlial growth factor(VEGF)and transforming growth factor-β2(TGF-β2)between the two groups(P>0.05);after treatment,the level of VEGF in the observation group was higher than that in the control group,and the level of TGF-β2 was lower than that in the control group(P<0.05).Before treatment,there were no significant differences in cuprum(Cu)and zinc(Zn)levels between the two groups(P>0.05);after treatment,the levels of Cu and Zn in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Huangqi granule combined with minoxidil in the treatment of seborrheic alopecia can improve the clinical treatment effect,promote the improvement of sex hormones,growth factors and trace elements levels,and has high safety,which is worthy of promotion.