Effect of Xiaoer Jiegan granules combined with cefuroxime axetil in the treatment of acute upper respiratory infection in children and its influence on children's condition
Objective To analyze the effect of Xiaoer Jiegan granules combined with cefuroxime axetil in the treatment of acute upper respiratory infection(AURI)in children.Methods A total of 200 children with AURI admitted in our hospital from January 2019 to December 2021 were selected as the research objects.According to the random number table method,the children were divided into control group(n=100,cefuroxime axetil)and study group(n=100,Xiaoer Jiegan granules combined with cefuroxime axetil).The clinical efficacy,incidence of adverse reactions,serum indexes and immune function indexes of the two groups were compared.Results The total effective rate of treatment in the study group was 94.00%,which was higher than 80.00%in the control group(P<0.05).There were no significant differences in the incidences of dizziness,dry mouth,diarrhea,rash and total incidence of adverse reactions between the two groups(P>0.05).After treatment,the levels of serum amyloid A(SAA),soluble interleukin-2 receptor(sIL-2R),interleukin-6(IL-6),cyclooxygenase-2(COX-2)and intercellular adhesion molecule-1(ICAM-1)in the study group were lower than those in the control group(P<0.05).After treatment,CD4+ and CD4+/CD8+ in the study group were higher than those in the control group,and CD8+ was lower than that in the control group(P<0.05).Conclusion Xiaoer Jiegan granules combined with cefuroxime axetil in the treatment of AURI in children can improve the serum indexes and immune function of children,thereby improving the overall efficacy and controlling the progression of the disease,and the combined regimen does not increase the risk of adverse reactions,which can be further promoted in clinical practice.
acute upper respiratory infectionXiaoer Jiegan granulecefuroxime axetilimmune function