首页|小儿解感颗粒联合头孢呋辛酯治疗小儿急性上呼吸道感染的效果及对患儿病情的影响

小儿解感颗粒联合头孢呋辛酯治疗小儿急性上呼吸道感染的效果及对患儿病情的影响

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目的 分析小儿解感颗粒联合头孢呋辛酯治疗小儿急性上呼吸道感染(AURI)的效果.方法 选择2019年1月至2021年12月我院收治的200 例AURI患儿为研究对象,根据随机数字表法将其分为对照组(n=100,头孢呋辛酯)和研究组(n=100,小儿解感颗粒联合头孢呋辛酯).比较两组的临床疗效、不良反应发生情况、血清指标和免疫功能指标.结果 研究组的治疗总有效率为 94.00%,高于对照组的 80.00%(P<0.05).两组的头晕、口干、腹泻、皮疹发生率及不良反应总发生率比较,差异无统计学意义(P>0.05).治疗后,研究组的血清淀粉样蛋白A(SAA)、可溶性白细胞介素-2 受体(sIL-2R)、白细胞介素-6(IL-6)、环氧化酶-2(COX-2)及细胞间黏附分子-1(ICAM-1)水平均低于对照组(P<0.05).治疗后,研究组的CD4+、CD4+/CD8+高于对照组,CD8+低于对照组(P<0.05).结论 小儿解感颗粒联合头孢呋辛酯治疗小儿AURI能够改善患儿的血清指标和免疫功能,进而能够提高总体疗效,控制病情进展,且联合方案并未增加不良反应发生风险,临床可进一步推广运用.
Effect of Xiaoer Jiegan granules combined with cefuroxime axetil in the treatment of acute upper respiratory infection in children and its influence on children's condition
Objective To analyze the effect of Xiaoer Jiegan granules combined with cefuroxime axetil in the treatment of acute upper respiratory infection(AURI)in children.Methods A total of 200 children with AURI admitted in our hospital from January 2019 to December 2021 were selected as the research objects.According to the random number table method,the children were divided into control group(n=100,cefuroxime axetil)and study group(n=100,Xiaoer Jiegan granules combined with cefuroxime axetil).The clinical efficacy,incidence of adverse reactions,serum indexes and immune function indexes of the two groups were compared.Results The total effective rate of treatment in the study group was 94.00%,which was higher than 80.00%in the control group(P<0.05).There were no significant differences in the incidences of dizziness,dry mouth,diarrhea,rash and total incidence of adverse reactions between the two groups(P>0.05).After treatment,the levels of serum amyloid A(SAA),soluble interleukin-2 receptor(sIL-2R),interleukin-6(IL-6),cyclooxygenase-2(COX-2)and intercellular adhesion molecule-1(ICAM-1)in the study group were lower than those in the control group(P<0.05).After treatment,CD4+ and CD4+/CD8+ in the study group were higher than those in the control group,and CD8+ was lower than that in the control group(P<0.05).Conclusion Xiaoer Jiegan granules combined with cefuroxime axetil in the treatment of AURI in children can improve the serum indexes and immune function of children,thereby improving the overall efficacy and controlling the progression of the disease,and the combined regimen does not increase the risk of adverse reactions,which can be further promoted in clinical practice.

acute upper respiratory infectionXiaoer Jiegan granulecefuroxime axetilimmune function

赵月华

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河南科技大学第一附属医院,河南 洛阳,471000

急性上呼吸道感染 小儿解感颗粒 头孢呋辛酯 免疫功能

2024

临床医学研究与实践

临床医学研究与实践

ISSN:
年,卷(期):2024.9(11)
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