Research progress on anti-acute myeloid leukemia effect of artemisinin and its derivatives
Artemisinin and its derivatives are a class of natural drugs with multiple biological activities,which have been found that it not only has a significant anti-malaria effect,but also has a strong anti-acute myeloid leukemia(AML)effect.Artemisinin and its derivatives can exert anti-AML effects by promoting the production of reactive oxygen species(ROS),inducing cellular autophagy,down-regulating the anti-apoptotic proteins myeloid leukemia 1(MCL-1)and B-cell lymphoma-2(BCL-2),and activating the phosphatase and tensin homolog(PTEN)/Protein Kinase B(AKT)pathway.AML is a malignant tumor of the hematological system,characterized by high remission rate,easy recurrence and poor prognosis.At present,the clinical first-line treatment of AML has not changed for decades.It is urgent to find a new treatment to improve the prognosis.In this paper,we review the progress of research on the anti-AML effects of artemisinin and its derivatives in recent years,in order to provide ideas and directions for new therapeutic options for AML.
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