摘要
活性氧(ROS)是细胞内一类氧的单电子还原产物,具有很高的氧化性,能参与细胞内多种生命活动,且与肾癌的发生发展和治疗有很大关系.诱导凋亡、自噬和周期阻滞的发生是目前治疗癌症的常规机制,而在肾癌中ROS又与其有着密切联系.放疗在以往肾癌的治疗中并不常见,调节ROS结合放疗是一种新的治疗手段.本文将对ROS在肾癌细胞的凋亡、自噬、细胞周期阻滞和放化疗过程中所起的作用以及靶向ROS所面临的困难进行综述.
Abstract
Reactive oxygen species(ROS)is a single electron reduction product of a class of intracellular oxygen,with highly oxidative.It can participate in various cellular life activities and is closely related to the occurrence,development,and treatment of renal carcinoma.Inducing apoptosis,autophagy,and cycle arrest are currently the conventional mechanism for treating cancer,and ROS is closely related to them in renal carcinoma.Radiation therapy has not been common in the treatment of renal carcinoma,but modulation of ROS in combination with radiation therapy is a new treatment way.This article will review the role of ROS in apoptosis,autophagy,cell cycle arrest,and chemoradiotherapy in renal carcinoma cells,as well as the challenges faced in targeting ROS.
维普
万方数据