Clinical effect of rt-PA intravenous thrombolysis on patients with acute cerebral infarction accompanied by HMCAS and its influences on serum t-PA,PAI-1 levels and immune function
Objective To investigate the clinical effect of recombinant tissue-type plasminogen activator(rt-PA)intravenous thrombolysis on patients with acute cerebral infarction accompanied by hyperdense middle cerebral artery sign(HMCAS)and its influences on serum tissue-type plasminogen activator(t-PA),plasminogen activitor inhibitor-1(PAI-1)levels and immune function.Methods The clinical data of 132 patients with acute cerebral infarction accompanied by HMCAS treated in our hospital from March 2020 to June 2022 were selected for study.According to the treatment plan,the patients were divided into control group(n=66)and observation group(n=66).The control group was given conventional treatment,and the observation group was treated with rt-PA intravenous thrombolysis on this basis.The therapeutic effects of the two groups were compared.Results After 7 d of treatment,the National Institute of Health Stroke Scale(NIHSS)score of both groups decreased,and that in the observation group was significantly lower than the control group(P＜0.05).After 7 d of treatment,the t-PA level in the observation group was significantly higher than that in the control group,and the PAI-1 level was significantly lower than that in the control group(P＜0.05).After 7 d of treatment,the CD3+,CD4+,immunoglobulin G(IgG)and immunoglobulin M(IgM)levels in both groups were higher than those before treatment,and those in the observation group were significantly higher than the control group(P＜0.05).The Barthel index score and proportion of Modified Rankin Scale(mRS)score from 0 to 2 in the observation group were significantly higher than those in the control group(P＜0.05).Conclusion rt-PA intravenous thrombolysis in the treatment of acute cerebral infarction accompanied by HMCAS has a good effect,which can effectively improve the levels of t-PA and PAI-1,and enhance immune function,with high safety.
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