Clinical effect of Danhong injection combined with butylphthalide injection in the treatment of patients with acute cerebral infarction and its influence on oxidative stress
Objective To analyze the clinical effect of Danhong injection combined with butylphthalide injection in the treatment of patients with acute cerebral infarction and its influence on oxidative stress.Methods Sixty-four patients with acute cerebral infarction admitted in our hospital from December 2020 to December 2022 were divided into routine group and observation group according to the different treatment plan,with 32 cases in each group.The routine group was treated with butylphthalide injection on the basis of basic treatment,and the observation group was treated with Danhong injection on the basis of the routine group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the routine group,and the difference was statistically significant(P＜0.05).After treatment,the levels of neuron-specific enolase(NSE),S100-βprotein,8-hydroxydeoxyguanosine(8-OHdG)and malondialdehyde(MDA)in the observation group were significantly lower than those in the routine group,the levels of superoxide dismutase(SOD),total antioxidant capacity(T-AOC)and glutathione(GSH)were significantly higher than those in the routine group,and the differences were statistically significant(P＜0.05).After treatment,the maximum blood flow velocity(Vmax),minimum blood flow velocity(Vmin)and mean blood flow(Qmean)of the basilar artery in the observation group were significantly higher than those in the routine group,and the peripheral resistance(RV)was significantly lower than that in the routine group,and the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Danhong injection combined with butylphthalide injection in the treatment of patients with acute cerebral infarction can achieve safe and efficient clinical effect,and improve oxidative stress response.
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