Application effect of aflibercept in patients with proliferative diabetic retinopathy
Objective To analyze the application effect of aflibercept in patients with proliferative diabetic retinopathy(PDR).Methods A total of 80 patients with PDR admitted in our hospital from July 2019 to July 2021 were selected as the objects and randomly divided into control group(n=40,treated with vitrectomy)and study group(n=40,treated with aflibercept+vitrectomy).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was 95.00％,which was higher than 77.50％in the control group(P＜0.05).After treatment,the peak systolic velocity(PSV)and end diastolic velocity(EDV)in the study group were higher than those in the control group,and the resistance index(RI)and the levels of vascular endothelial growth factor(VEGF),erythropoietin(EPO),angiopoietin-2(Ang-2),hypoxia inducible factor-1α(HIF-1α)and miR-210 were lower than those in the control group(P＜0.05).At 1 week,1 month and 3 months after operation,the best corrected visual acuity of the study group was higher than that of the control group(P＜0.05).Conclusion The aflibercept+vitrectomy can achive ideal results in the treatment of PDR patients,improve hemodynamics,serum indicators and enhance postoperative visual acuity.It is worthy of clinical promotion and application.
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