Effect of Shugan Lidan Jianpi Huoxue prescription combined with ursodeoxycholic acid in the treatment of patients with primary biliary cholangitis and its influence on serum autoantibody levels
Objective To analyze the effect of Shugan Lidan Jianpi Huoxue prescription combined with ursodeoxycholic acid(UDCA)in the treatment of patients with primary biliary cholangitis(PBC).Methods A total of 80 patients with PBC admitted in our hospital from June 2019 to June 2021 were selected as the research objects and divided into control group(n=40,UDCA)and study group(n=40,Shugan Lidan Jianpi Huoxue prescription+UDCA)according to the random number table method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was higher than that in the control group(P＜0.05).After treatment,the levels of hyaluronic acid(HA),laminin(LN),procollagen type Ⅲ(PC-Ⅲ)and type Ⅳ collagen(Ⅳ-C)in the two groups decreased,and those in the study group were lower than the control group(P＜0.05).After treatment,the levels of total bilirubin(TBIL),alkaline phosphatase(ALP),gamma-glutamyltransferase(GGT)and aspartate aminotransferase(AST)in the two groups decreased,and those in the study group were lower than the control group(P＜0.05).After treatment,the levels of immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)in the two groups decreased,and those in the study group were lower than the control group(P＜0.05).Conclusion The Shugan Lidan Jianpi Huoxue prescription combined with UDCA in the treatment of PBC patients has definite curative effect,it can not only improve the level of autoantibodies and liver function,but also regulate the indexes of liver fibrosis,which can be further promoted and applied in clinical practice.
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