Two-sample Mendelian randomization analysis of the relationship between drinking frequency and the risk of cardiovascular disease
Objective To analyze the correlation between drinking frequency and cardiovascular disease by Mendelian randomization(MR).Methods Genome wide association study(GWAS)data of drinking frequency and cardiovascular disease were obtained from the UKBiobank and FinnGen databases.Single nucleotide polymorphisms(SNPs)independently associated with drinking frequency were obtained as instrumental variables from the GWAS summary data of drinking frequency in the UKBiobank database.The correlation between drinking frequency and cardiovascular disease was analyzed by instrumental variables and fixed-effects inverse-variance-weighted(IVW),MR-Egger and Weighted median.Results A total of 99 SNPs were screened to be associated with drinking frequency.The results of IVW showed that an increased in drinking frequency leads to an increased the risk of heart failure and hypertension(P=0.004,0.018);for every increase in drinking frequency,the risk of heart failure increased by 1.234 times[odds ratios(OR)(95%CI)=1.234(1.071-1.422)],and the risk of hypertension increased by 1.191 times[OR(95%CI)=1.191(1.030-1.376)];there was no causal relationship between drinking frequency and risk of coronary heart disease[P=0.977,OR(95%CI)=0.997(0.797-1.247)].The results of MR-Egger regression showed that there was no horizontal pleiotropy in the study(P>0.05).Conclusion There is a causal relationship between drinking frequency and heart failure and hypertension.
万方数据
维普
