Explore the pharmacological mechanism of effective components of Shengmaiyin based on system pharmacology
Objective To explore the complex relationship of the active ingredients,targets and disease of Shengmaiyin based on systematic pharmacology method.Methods The active ingredients of Shengmaiyin were screened and the targets were predicted on traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP)with oral bioavailability(OB)(Renshen and Wuweizi OB≥60%,Maidong OB≥45%)and drug-likeness(DL)≥0.1,and the active ingredient-target-disease network was constructed.Results A total of 17 active ingredients were screened,including 11 components of Renshen,2 components of Maidong,and 4 components of Wuweizi.A total of 79 targets and 13 diseases were obtained.The active ingredients and targets in the network diagram were connected by 176 edges,that is,each active ingredient corresponded to about 10.3 targets on average,and each target was associated with 4.6 active ingredients on average.The target and the disease are connected by a total of 235 edges.Conclusion This study intuitively constructed the interaction between the active ingredients,target proteins and diseases of Shengmaiyin,thus revealing the efficacy of Shengmaiyin in a variety of clinical diseases,and providing theoretical basis for further research on the mechanism of Shengmaiyin.
万方数据
维普
