Clinical effect of coenzyme Q10 combined with fasudil in the treatment of patients with unstable angina pectoris of coronary heart disease
Objective To analyze the clinical effect of coenzyme Q10 combined with fasudil in the treatment of patients with unstable angina pectoris of coronary heart disease.Methods A total of 92 patients with unstable angina pectoris of coronary heart disease admitted from August 2020 to August 2022 were selected as the research objects and divided into routine group(46 cases,fasudil treatment)and observation group(46 cases,coenzyme Q10 combined with fasudil treatment)by random method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 97.83%,which was higher than 84.78%in the routine group,and the difference was statistically significant(P<0.05).After treatment,the levels of brain natriuretic peptide(BNP),cardiac troponin T(cTnT),soluble growth stimulator gene 2 protein(sST2),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),homocysteine(HCY),thymic stromal lymphopoietin(TSLP)and endothelin(ET)in the observation group were lower than those in the routine group,and the levels of adiponectin(APN)and nitric oxide(NO)were higher than those in the routine group,the differences were statistically significant(P<0.05).After treatment,the CD4+ and CD4+/CD8+in the observation group were higher than those in the routine group,and the CD8+ was lower than that in the routine group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse drug reactions between the two groups during treatment(P>0.05).Conclusion Coenzyme Q10 combined with fasudil in the treatment of patients with unstable angina pectoris of coronary heart disease can effectively promote the repair of myocardial injury,alleviate the inflammatory response,regulate the immune function,promote the rapid outcome of the disease,and does not increase the incidence of adverse reactions,which is a safe and efficient treatment regimen.It is worthy of clinical promotion and application.
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