Study on the correlation between tyrosine hydroxylase content in peripheral blood and first-episode depression
Objective To explore the correlation between the content of tyrosine hydroxylase(TH)in peripheral blood and first-episode depression,and to provide scientific basis for elucidating the clinical diagnosis and pathogenesis of depression.Methods Forty patients with first-episode depression who were treated in our hospital from July 2021 to September 2022 were selected as case group,and 46 healthy people who underwent physical examination in the physical examination center of our hospital were selected as control group.The Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)scores were performed in both groups,and peripheral blood was collected to determine TH content.The TH content of the two groups and the TH content in different gender and different age groups were compared;the correlation between TH content and HAMA and HAMD scores were analyzed by partial correlation;the diagnostic value of TH for depression was evaluated by the area under curve(AUC)of the receiver operating characteristic curve(ROC).Results The TH content in the case group was significantly lower than that in the control group(P<0.05).The HAMA and HAMD scores of the case group were negatively correlated with TH content(P<0.05).ROC curve analysis showed that the AUC of TH in predicting depression was 0.660.Conclusion The decrease of TH content in peripheral blood may be related to the occurrence and development of first-episode depression.It can be used as a biomarker of depression and has certain clinical value in predicting depression.
NETL
NSTL
万方数据
维普
