Effects of butylphthalide combined with low molecular weight heparin on hemorheology and neurological function in patients with acute progressive cerebral infarction
Objective To investigate the effects of butylphthalide combined with low molecular weight heparin on hemorheology and neurological function in patients with acute progressive cerebral infarction.Methods A total of 60 patients with acute progressive cerebral infarction admitted in our hospital from January 2020 to January 2023 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 30 cases in each group.The control group was treated with low molecular weight heparin,and the observation group was treated with butylphthalide on the basis of the control group.The clinical efficacy,inflammatory factor levels,vascular endothelial function indexes,hemorheology,neurological function and daily living ability were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),homocysteine(Hcy),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),whole blood high shear viscosity,whole blood low shear viscosity,plasma specific viscosity,fibrinogen,and the National Institutes of Health Stroke Scale(NIHSS)score in the two groups decreased,the level of nitric oxide(NO)and Activities of Daily Living(ADL)score increased,and those in the observation group were better than the control group,and the differences were statistically significant(P<0.05).Conclusion Butylphthalide combined with low molecular weight heparin is effective in the treatment of patients with acute progressive cerebral infarction.It can improve the hemorheology and vascular endothelial function of patients,reduce the inflammatory response,and improve the neurological function and daily living ability.
butylphthalidelow molecular weight heparinacute progressive cerebral infarctionhemorheologyneurological function
NETL
NSTL
万方数据
维普
