Effects of NIPPV and HFNC alternating therapy on arterial blood gas indexes and inflammatory factors levels in patients with respiratory failure caused by severe pneumonia
Objective To study the effects of non-invasive positive pressure ventilation(NIPPV)and humidified high flow nasal cannula oxygen therapy(HFNC)alternating therapy on arterial blood gas indexes and inflammatory factors levels in patients with respiratory failure caused by severe pneumonia.Methods Eighty patients with respiratory failure caused by severe pneumonia admitted in our hospital from April 2021 to April 2022 were selected as the study objects and divided into control group(n=40)and observation group(n=40)according to treatment methods.The control group was treated with single NIPPV,and the observation group was treated with NIPPV and HFNC alternating therapy.The therapeutic effects of the two groups were compared.Results After 2 h of treatment,respiration rate(RR),heart rate(HR)and mean arterial pressure(MAP)in both groups were lower than those before treatment,those in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).After 2 h of treatment,arterial oxygen saturation(SaO2)and arterial partial pressure of oxygen(PaO2)in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05);after 2 h of treatment,there was no significant difference in arterial partial pressure of carbon dioxide(PaCO2)between the two groups(P>0.05).After 1 d of treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and high-sensitivity C-reactive protein(hs-CRP)in two groups were lower than those before treatment,those in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).Conclusion The NIPPV and HFNC alternating therapy applied in the emergency treatment of patients with respiratory failure caused by severe pneumonia has remarkable effect,which can improve hemodynamics,increase blood oxygen indexes,and reduce inflammatory response.
NETL
NSTL
万方数据
维普
