摘要
目的 分析难治性癫痫患者采取左乙拉西坦片与卡马西平片口服治疗对临床症状的缓解效果.方法 将我院 2020年 1 月至 2021 年 12 月收治的 100 例难治性癫痫患者为研究对象,以随机法将其分为卡马西平片组(50例,卡马西平片口服治疗)和左乙拉西坦片组(50例,左乙拉西坦片口服治疗).比较两组的治疗效果.结果 左乙拉西坦片组的治疗总有效率显著高于卡马西平片组(P＜0.05).治疗前,两组的癫痫发作频率、持续时间及脑电频率无明显差异(P＞0.05);治疗后,左乙拉西坦片组的癫痫发作频率、持续时间及脑电频率θ、δ显著低于卡马西平片组,脑电频率α显著高于卡马西平片组(P＜0.05).治疗前,两组的免疫球蛋白A(IgA)、免疫球蛋白G(IgG)及免疫球蛋白M(IgM)水平无明显差异(P＞0.05);治疗后,左乙拉西坦片组的IgA、IgG及IgM水平显著高于卡马西平片组(P＜0.05).治疗前,两组的S-100β蛋白、髓鞘碱性蛋白(MBP)、神经元特异性烯醇化酶(NSE)及脑源性神经营养因子(BDNF)水平无明显差异(P＞0.05);治疗后,左乙拉西坦片组的S-100β蛋白、MBP及NSE水平显著低于卡马西平片组,BDNF水平显著高于卡马西平片组(P＜0.05).左乙拉西坦片组的药副反应总发生率显著低于卡马西平片组(P＜0.05).结论 左乙拉西坦片治疗难治性癫痫患者具有更高的临床应用价值.
Abstract
Objective To analyze the effects of oral treatment of levetiracetam tablets and carbamazepine tablets on clinical symptoms in patients with refractory epilepsy.Methods A total of 100 patients with refractory epilepsy admitted in our hospital from January 2020 to December 2021 were selected as the research objects and randomly divided into carbamazepine tablets group(50 cases,oral treatment of carbamazepine tablets)and levetiracetam tablets group(50 cases,oral treatment of levetiracetam tablets).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the levetiracetam tablets group was significantly higher than that in the carbamazepine tablets group(P<0.05).Before treatment,there were no significant difference in seizure frequency,duration and EEG frequency between the two groups(P>0.05);after treatment,the seizure frequency,duration and EEG frequency θ and δ of the levetiracetam tablets group were significantly lower than those of the carbamazepine tablets group,and the EEG frequency α was significantly higher than that of the carbamazepine tablets group(P<0.05).Before treatment,there were no significant difference in the levels of immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)between the two groups(P>0.05);after treatment,the levels of IgA,IgG and IgM in the levetiracetam tablets group were significantly higher than those in the carbamazepine tablets group(P<0.05).Before treatment,there were no significant difference in the levels of S-100β protein,myelin basic protein(MBP),neuron-specific enolase(NSE)and brain-derived neurotrophic factor(BDNF)between the two groups(P>0.05);after treatment,the levels of S-100β protein,MBP and NSE in the levetiracetam tablets group were significantly lower than those in the carbamazepine tablets group,and the level of BDNF was significantly higher than that in the carbamazepine tablets group(P<0.05).The total incidence of adverse drug reactions in the levetiracetam tablets group was significantly lower than that in the carbamazepine tablets group(P<0.05).Conclusion The levetiracetam tablets in the treatment of patients with refractory epilepsy has higher clinical application value.
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维普
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