Correlation between serum homocysteine level and cognitive function in patients with chronic schizophrenia
Objective To analyze the correlation between serum homocysteine(Hcy)level and cognitive function in patients with chronic schizophrenia.Methods A total of 85 patients with chronic schizophrenia who were hospitalized in our hospital from January to December 2021 were selected as the observation group,and 50 healthy volunteers were recruited as the control group.The serum Hcy level was detected in both groups,and the results were statistically compared.Spearman correlation analysis was used to analyze the correlation between Hcy level and cognitive function in the observation group.Results The serum Hcy level of the observation group was higher than that of the control group(P<0.01).The serum Hcy level of patients with Positive and Negative Syndrome Scale(PANSS)grade 2 was higher than that of patients with PANSS grade 1(P=0.000);The serum Hcy level of patients with PANSS grade 3 was higher than that of patients with PANSS grade 1 and grade 2(P=0.000).The Montreal Cognitive Assessment(MoCA)score of patients with PANSS grade 1 was higher than that of patients with PANSS grade 2 and grade 3(P=0.000);there were no significant difference in MoCA score between patients with PANSS grade 2 and grade 3(P=0.753).The serum Hcy level in patients with normal MoCA score was lower than that in patients with abnormal MoCA score(P=0.000).The level of Hcy of patietns was positively correlated with PANSS grade(P<0.05);the level of Hcy of patients was negatively correlated with MoCA score(P<0.05).Conclusion The level of serum Hcy in patients with chronic schizophrenia is significantly increased,and the higher the level of Hcy,the more serious the mental symptoms and the worse the cognitive function.
chronic schizophreniahomocysteinecognitive function
NETL
NSTL
万方数据
维普
