慢性精神分裂症患者血清同型半胱氨酸水平与认知功能的相关性
Correlation between serum homocysteine level and cognitive function in patients with chronic schizophrenia
褚林娟 1陈彩红 2严丽 3颜敏 1凤燕琼4
作者信息
- 1. 上海市民政第二精神卫生中心:检验科,上海,201319
- 2. 上海市民政第二精神卫生中心:二病区,上海,201319
- 3. 上海市民政第二精神卫生中心:综合治疗科,上海,201319
- 4. 上海市民政第二精神卫生中心:院部,上海,201319
- 折叠
摘要
目的 分析慢性精神分裂症患者血清同型半胱氨酸(Hcy)水平与认知功能的相关性.方法 选取2021年1 月至 12月在我院接受住院治疗的 85 例慢性精神分裂症患者为观察组,另招募 50 名健康志愿者为对照组.两组均进行血清Hcy水平检测,统计比较检测结果.采用Spearman相关性分析观察组Hcy水平与认知功能的相关性.结果 观察组的血清Hcy水平高于对照组(P＜0.01).阳性与阴性症状量表(PANSS)2 级患者的血清Hcy水平高于PANSS 1 级患者(P=0.000);PANSS 3 级患者的血清Hcy水平高于PANSS 1、2 级患者(P=0.000).PANSS 1 级患者的蒙特利尔认知评估量表(MoCA)评分高于PANSS 2、3 级患者(P=0.000);PANSS 2 级与 3 级患者的MoCA评分比较,差异无统计学意义(P=0.753).MoCA评分正常患者的血清Hcy水平低于MoCA评分异常患者(P=0.000).患者的Hcy水平与PANSS分级呈正相关(P<0.05);患者的Hcy水平与MoCA评分呈负相关(P<0.05).结论 慢性精神分裂症患者血清Hcy水平显著升高,且Hcy水平越高,其精神症状越严重,认知功能越差.
Abstract
Objective To analyze the correlation between serum homocysteine(Hcy)level and cognitive function in patients with chronic schizophrenia.Methods A total of 85 patients with chronic schizophrenia who were hospitalized in our hospital from January to December 2021 were selected as the observation group,and 50 healthy volunteers were recruited as the control group.The serum Hcy level was detected in both groups,and the results were statistically compared.Spearman correlation analysis was used to analyze the correlation between Hcy level and cognitive function in the observation group.Results The serum Hcy level of the observation group was higher than that of the control group(P<0.01).The serum Hcy level of patients with Positive and Negative Syndrome Scale(PANSS)grade 2 was higher than that of patients with PANSS grade 1(P=0.000);The serum Hcy level of patients with PANSS grade 3 was higher than that of patients with PANSS grade 1 and grade 2(P=0.000).The Montreal Cognitive Assessment(MoCA)score of patients with PANSS grade 1 was higher than that of patients with PANSS grade 2 and grade 3(P=0.000);there were no significant difference in MoCA score between patients with PANSS grade 2 and grade 3(P=0.753).The serum Hcy level in patients with normal MoCA score was lower than that in patients with abnormal MoCA score(P=0.000).The level of Hcy of patietns was positively correlated with PANSS grade(P<0.05);the level of Hcy of patients was negatively correlated with MoCA score(P<0.05).Conclusion The level of serum Hcy in patients with chronic schizophrenia is significantly increased,and the higher the level of Hcy,the more serious the mental symptoms and the worse the cognitive function.
关键词
慢性精神分裂症/同型半胱氨酸/认知功能Key words
chronic schizophrenia/homocysteine/cognitive function引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据