Effects of restrictive fluid resuscitation combined with body temperature management on hypothermia and stress response in patients with multiple trauma and hemorrhagic shock
Objective To analyze the effects of restrictive fluid resuscitation combined with body temperature management on hypothermia and stress response in patients with multiple trauma and hemorrhagic shock.Methods A total of 80 patients with multiple trauma and hemorrhagic shock admitted in our hospital from January to December 2020 were selected as the research objects.According to the difference of treatment plan,the patients were divided into conventional group and observation group,with 40 cases in each group.The conventional group was treated with traditional fluid resuscitation combined with body temperature management,and the observation group was treated with restrictive fluid resuscitation combined with body temperature management.The therapeutic effects of the two groups were compared.Results The total incidence of adverse events in the observation group was significantly lower than that in the conventional group(P<0.05).On admission,there were no significant differences in the levels of tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),interleukin-10(IL-10),cortisol(Cor),superoxide dismutase(SOD)and malondialdehyde(MDA)between the two groups(P>0.05);at the time of resuscitation and 2 h after resuscitation,the levels of TNF-α,IL-8,Cor and MDA in the observation group were lower than those in the conventional group,and the levels of IL-10 and SOD were higher than those in the conventional group(P<0.05).On admission,there were no significant differences in thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT),cardiac output(CO),cardiac index(CI)and global end diastolic volume index(GEDVI)between the two groups(P>0.05);at the time of resuscitation and 2 h after resuscitation,TT,PT and APTT in the observation group were shorter than those in the conventional group,CO,CI and GEDVI were higher than those in the conventional group(P<0.05).Conclusion Restrictive fluid resuscitation combined with body temperature management can effectively shorten the recovery time of patients with multiple trauma and hemorrhagic shock,reduce the incidence of adverse events,quickly relieve inflammation and stress response,and promote the recovery of cardiac function.
multiple trauma and hemorrhagic shockrestrictive fluid resuscitationbody temperature managementhypothermiastress response
NETL
NSTL
万方数据
维普
