Sepsis is a syndrome of organ dysfunction caused by immune response disorder caused by infection,with high morbidity and mortality.The pathophysiology of sepsis immune response is usually divided into two stages:acute inflammatory response and subsequent immunosuppression.The immunosuppression complicated by sepsis makes patients vulnerable to hospital and opportunistic infections,resulting in prolonged hospital stay and increased late death in patients with sepsis.The pathogenesis of sepsis immunosuppression is complex and diverse.In-depth understanding of its pathogenesis can help timely detect the risk of immunosuppression in patients in clinic,so as to carry out targeted treatment and improve the prognosis of patients with sepsis.This article reviews the pathogenesis of sepsis immunosuppression.
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