Effect of propofol tenofovir fumarate combined with double plasma molecular adsorption system in the treatment of hepatitis B-related acute-on-chronic liver failure
Objective To analyze the effect of propofol tenofovir fumarate combined with double plasma molecular adsorption system in the treatment of hepatitis B-related acute-on-chronic liver failure and its influences on interferon-γ(IFN-γ)and miR-223-3p.Methods A total of 100 patients with hepatitis B-related acute-on-chronic liver failure admitted in our hospital from January 2018 to January 2022 were selected as the research objects,and the patients were randomly divided into conventional group(50 cases,double plasma molecular adsorption system treatment)and observation group(50 cases,propofol tenofovir fumarate combined with double plasma molecular adsorption system treatment).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the conventional group(P<0.05).After treatment,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBil)in the observation group were lower than those in the conventional group,and the prothrombin time activity(PTA)was higher than that in the conventional group(P<0.05).After treatment,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and relative expression of miR-223-3p in the observation group were lower than those in the conventional group,and the levels of interleukin-10(IL-10)and IFN-γ were higher than those in the conventional group(P<0.05).The total incidence of complications in the observation group was lower than that in the conventional group(P<0.05).Conclusion Propofol tenofovir fumarate combined with double plasma molecular adsorption system in the treatment of patients with hepatitis B-related acute-on-chronic liver failurecan can achieve ideal efficacy.
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