Objective To explore the feasibility and safety of 3D printed model-assisted posterior column screw internal fixation for acetabular fracture.Methods Eighty patients with acetabular fracture admitted in our hospital from January 2020 to June 2021 were selected as the study objects and divided into control group and observation group according to the parity of admission numbers,with 40 cases in each group.The control group underwent open reduction screw fixation via rectus abdominis side approach,and the observation group underwent 3D printed model-assisted posterior column screw internal fixation.The therapeutic effects of the two groups were compared.Results At 6 months after surgery,the Fugl-Meyer Assessment(FMA),Harris Hip Score(HHS)and Activities of Daily Living(ADL)scores in the observation group were significanty higher than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of complications of the observation group was significanty lower than that of the control group,and the difference was statistically significant(P<0.05).The operation duration,hospital stay and bone healing time of the observation group were significanty shorter than those of the control group,the intraoperative blood loss was significanty less than that of control group,and the differences were statistically significant(P<0.05).At 2 d after surgery,the CD4+,CD4+/CD8+and interleukin-10(IL-10)level in the observation group were significantly higher than those in the control group,while the CD8+and interleukin-6(IL-6)level were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).The excellent and good rate of long-term recovery of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion 3D printed model-assisted posterior column screw internal fixation can significantly improve the treatment effect of acetabular fracture and promote the recovery of acetabular function of patients,which has important clinical application value.