Detection of AMH and sex hormone levels in patients with premature ovarian failure and different subtypes of polycystic ovary syndrome
Objective To investigate the significance of detection of anti-Müllerian hormone(AMH)and sex hormone levels in patients with premature ovarian failure and different subtypes of polycystic ovary syndrome.Methods From July 2020 to July 2021,30 patients with premature ovarian failure admitted in our hospital were included in premature failure group,and 70 patients with polycystic ovary syndrome were included in polycystic group;at the same time,50 healthy women who underwent physical examinations were selected as control group.The polycystic group was divided into 17 cases of rare ovulation or oligo-anovulation(OA)+hyperandrogenism clinical manifestations or hyperandrogenemia(HA)+polycystic ovaries(PCO)group,20 cases of OA+HA group,18 cases of OA+PCO group and 15 cases of HA+PCO group according to different subtypes.The levels of AMH and sex hormones in each group were compared.Results The levels of AMH and estradiol(E2)in the premature failure group were lower than those in the control group,and the levels of follicle stimulating hormone(FSH),luteinizing hormone(LH)and testosterone(T)were higher than those in the control group(P<0.05);the levels of AMH,E2,LH and T in the polycystic group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were statistically significant differences in the levels of AMH,LH and T in patients with different subtypes of polycystic ovary syndrome(P<0.05).Among the 70 patients with polycystic ovary syndrome,25 cases were successfully pregnant to delivery,45 cases were unsuccessfully pregnant or aborted;there were no significant differences in the levels of AMH,E2,FSH,LH and T in patients with polycystic ovary syndrome with different pregnancy outcomes(P>0.05).Among 30 patients with premature ovarian failure,4 cases were successfully pregnant to delivery,and 26 cases were unsuccessfully pregnant or aborted;the levels of AMH and E2 in patients with successfully pregnancy to delivery were higher than those in patients with unsuccessfully pregnancy or abortion,and the levels of LH and T were lower than those in patients with unsuccessfully pregnancy or abortion(P<0.05).Conclusion The AMH and sex hormone levels of patients with premature ovarian failure and different subtypes of polycystic ovary syndrome are different.AMH and sex hormone levels can reflect the ovarian function of patients,and have good value in evaluating the ovarian function of patients with premature ovarian failure and different subtypes of polycystic ovary syndrome,but there is no obvious relationship with the pregnancy of patients with polycystic ovary syndrome,and there is a certain relationship with the pregnancy of patients with premature ovarian failure,which is worth promoting.
万方数据
维普
