Research progress on eosinophilic chronic rhinosinusitis and A20
Chronic rhinosinusitis(CRS)is a chronic inflammatory disease of the nasal cavity and paranasal sinuses.The recurrence rate of eosinophilic CRS after surgery can be close to 50%,and the infiltration of eosinophils is obvious,which is related to the activation of nuclear factor-κB(NF-κB)channels.This article reviews the structural characteristics,biological functions,and relationship with inflammation and tumor related diseases of zinc finger protein A20.Consider it as a negative regulatory factor of NF-κB is involved in multiple inflammatory and tumor diseases,playing a role in inhibiting inflammation and tumors,providing new ideas for the diagnosis and treatment of high recurrence rate eosinophilic CRS.
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