Explore the mechanism of Danggui Shaoyao powder in regulating coagulation function and improving prethrombotic state in pregnant rats based on the theory of"unfavorable blood is water"
Objective To explore the mechanism of Danggui Shaoyao powder in regulating coagulation function and improving prethrombotic state in pregnant rats based on the theory of"unfavorable blood is water".Methods A total of 60 8-week-old SD female rats were selected and randomly divided into blank group,model group,low-dose Chinese medicine group[0.07 g/(100 g·d)],medium-dose Chinese medicine group[0.14 g/(100 g·d)],high-dose Chinese medicine group[0.28 g/(100 g·d)]and western medicine group[20 IU/(100 g·d)],with 10 rats in each group,all rats were mated with healthy male rats.On the first day of pregnancy,the prethrombotic state pregnancy rat model was established by adrenaline hydrochloride and ice water method,during the modeling process,2 rats in the model group died.The number of surviving embryos,the number of lost embryos and the rate of embryo loss were compared among the six groups;the levels of fibrinogen(FIB),antithrombin-Ⅲ(AT-Ⅲ),D-dimer(DD)and plasminogen(PLG)were compared among the six groups.Results The number of surviving embryos in the model group was lower than that in the blank group,and the number of lost embryos and the rate of embryo loss were higher than those in the blank group,and the differences were statistically significant(P<0.05);the number of surviving embryos in the medium-dose Chinese medicine group,high-dose Chinese medicine group and western medicine group was higher than that in the model group,and the difference was statistically significant(P<0.05);the number of lost embryos in the high-dose Chinese medicine group and western medicine group was lower than that in the model group,and the difference was statistically significant(P<0.05);the rate of embryo loss of the medium-dose Chinese medicine group,high-dose Chinese medicine group and western medicine group was lower than that of the model group,and the difference was statistically significant(P<0.05).The levels of FIB,DD and PLG in the model group were higher than those in the blank group,and the differences were statistically significant(P<0.05);the levels of FIB,DD and PLG in the low-dose Chinese medicine group,medium-dose Chinese medicine group,high-dose Chinese medicine group and western medicine group were lower than those in the model group,and the level of AT-Ⅲ was higher than that in the model group,and the differences were statistically significant(P<0.05).Conclusion Danggui Shaoyao powder can reduce the number of lost embryos,the rate of embryo loss and the levels of DD,PLG,FIB in prethrombotic state model rats,increase the number of surviving embryos and AT-Ⅲ level,ensure the normal development of embryos,improve blood hypercoagulability,promote microcirculation,and achieve antithrombotic effect.
NETL
NSTL
万方数据
