Correlation between HMGA1 and KRAS with gynecological tumors
With the improvement of social and economic level and people's attention to health needs,women's health has gradually received extensive attention from the society.However,the incidence and mortality of gynecological tumors are still high,and there is still a great controversy about the pathogenesis and treatment of gynecological tumors.Relevant studies have shown that,high mobility group protein A1(HMGA1)and Kirsten rat sarcoma viral oncogene homolog(KRAS)as oncogenes,can play an important role in the incidence and development of tumors by participating in a variety of ways.HMGA1 and KRAS have also been proved to be potential molecular markers in the diagnosis,treatment and prognosis of cancer,and can also be used as therapeutic targets to improve drug efficacy.In this paper,we first systematically review the research process of the two genes,then explain their role in the development of some common gynecological tumors diseases,and finally explore their effects on the treatment and prognosis of gynecological tumors,hoping to provide relevant basis for the study of HMGA1 and KRAS.
high mobility group protein A1Kirsten rat sarcoma viral oncogene homologgynecological tumorcervical cancerendometrial cancerovarian cancermolecular marker
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