Clinical effect of azithromycin sequential therapy combined with retained perfusion of acetylcysteine and budesonide under bronchoscopy in the treatment of refractory mycoplasma pneumoniae pneumonia in children
Objective To investigate the clinical effect of azithromycin sequential therapy combined with retained perfusion of acetylcysteine and budesonide under bronchoscopy in the treatment of refractory mycoplasma pneumoniae pneumonia(RMPP)in children.Methods A total of 90 children with RMPP admitted from April 2019 to March 2022 were selected as the research objects and divided into control group and observation group by random number table method,with 45 cases in each group.The control group was given azithromycin sequential therapy combined with bronchoalveolar lavage under bronchoscopy,while the observation group was given azithromycin sequential therapy combined with retained perfusion of acetylcysteine and budesonide under bronchoscopy.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the content of mycoplasma bacteria in alveolar lavage fluid of the observation group was better than that of the control group(P<0.05).After treatment,the levels of surfactant protein A(SP-A)and surfactant protein D(SP-D)in the observation group were lower than those in the control group(P<0.05).Conclusion Azithromycin sequential therapy combined with retained perfusion of acetylcysteine and budesonide under bronchoscopy is effective in the treatment of RMPP in children,it can reduce the content of mycoplasma bacteria in alveolar lavage fluid and the levels of SP-A and SP-D,which is worthy of promotion.
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