Effect of triamcinolone acetonide and econazole nitrate cream combined with miconazole nitrate in the treatment of fungal otitis externa and its influences on flora inhibition and inflammatory factors
Objective To analyze the effect of triamcinolone acetonide and econazole nitrate cream combined with miconazole nitrate in the treatment of fungal otitis externa and its influences on flora inhibition and inflammatory factors.Methods A total of 90 patients with fungal otitis externa admitted from July 2018 to December 2021 were selected as the research objects and divided into control group and observation group by random number table method,with 45 cases in each group.The control group was treated with miconazole nitrate,and the observation group was treated with triamcinolone acetonide and econazole nitrate cream on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The negative conversion rate of fungi in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of macrophage inflammatory protein-2(MIP-2),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)and interleukin-18(IL-18)between the two groups(P>0.05);after treatment,the levels of MIP-2,TNF-α,IFN-γ and IL-18 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in air conduction hearing threshold and air-bone gap between the two groups(P>0.05);after treatment,the air conduction hearing threshold and air-bone gap in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Triamcinolone acetonide and econazole nitrate cream combined with miconazole nitrate in the treatment of fungal otitis externa can improve the negative rate of fungi,regulate the levels of inflammatory factors,improve hearing function and enhance the therapeutic effect,which is worthy of promotion.
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