Effect of different doses of human immunoglobulin combined with aspirin in the treatment of Kawasaki disease in children and its influences on vascular endothelial function and oxidative stress indexes
Objective To explore the effect of different doses of human immunoglobulin combined with aspirin in the treatment of Kawasaki disease in children.Methods Sixty children with Kawasaki disease admitted in our department from April 2020 to April 2022 were selected and divided into control group and observation group by random number table method,with 30 cases in each group.The control group was treated with 1.0 g/(kg·d)human immunoglobulin combined with aspirin,and the observation group was treated with 2.0 g/(kg·d)human immunoglobulin combined with aspirin.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of anti-endothelial cell antibodies(AECA),anti-neutrophil cytoplasmic antibodies(ANCA)and vascular endothelial growth factor(VEGF)in the two groups decreased,and those in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in the two groups increased,and the levels of malondialdehyde(MDA)decreased,and those in the observation group were better than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of soluble interleukin-2 receptor(sIL-2R)and lipoprotein-associated phospholipase A2(Lp-PLA2)in the two groups decreased,and those in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The 2.0 g/(kg·d)human immunoglobulin combined with aspirin in the treatment of Kawasaki disease in children has better effect than that of 1.0 g/(kg·d)human immunoglobulin,which has more advantages in improving vascular endothelial function,oxidative stress response and immune inflammation,and has high safety.
human immunoglobulinaspirinKawasaki diseasevascular endothelial functionoxidative stress
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