Effect of nasal high-flow humidified oxygen therapy combined with budesonide and ambroxol hydrochloride in the treatment of neonatal pneumonia and its influences on TGF-β1 and LPS levels
Objective To explore the effect of nasal high-flow humidified oxygen therapy combined with budesonide and ambroxol hydrochloride in the treatment of neonatal pneumonia.Methods A total of 92 children with neonatal pneumonia admitted from January 2019 to February 2022 were selected as the research objects and divided into control group and observation group by random number table method,with 46 cases in each group.The control group was treated with budesonide combined with ambroxol hydrochloride,and the observation group was treated with nasal high-flow humidified oxygen therapy on the basis of the control group.The therapeutic effects of the two groups were compared.Results The body temperature recovery time,dyspnea relief time,lung rale disappearance time and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of transforming growth factor-β1(TGF-β1)and lipopolysaccharide(LPS)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of procalcitonin(PCT),soluble triggering receptor expressed on myeloid cells-1(sTREM-1)and nuclear factor-κB(NF-κB)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Nasal high-flow humidified oxygen therapy combined with budesonide and ambroxol hydrochloride is effective in the treatment of neonatal pneumonia.It can improve the clinical symptoms and inflammatory response,regulate the levels of TGF-β1 and LPS,and shorten the hospitalization time,which is worthy of promotion.
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