Effects of metoprolol tartrate combined with amiodarone hydrochloride tablets on cardiac function and adverse drug reactions in patients with coronary heart disease complicated with arrhythmia
Objective To investigate the effects of metoprolol tartrate combined with amiodarone hydrochloride tablets on cardiac function and adverse drug reactions in patients with coronary heart disease(CHD)complicated with arrhythmia.Methods A total of 96 CHD complicated with arrhythmia patients admitted from January 2021 to June 2022 were selected as the research objects and randomly divided into single group and combined group,with 48 cases in each group.The single group was treated with amiodarone hydrochloride tablets,and the combined group was treated with metoprolol tartrate on the basis of the single group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the combined group was significantly higher than that in the single group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)of the combined group was higher than that of the single group,and the left ventricular end-systolic diameter(LVESD),left ventricular end-systolic volume(LVESV)and left ventricular end-diastolic volume(LVEDV)were smaller than those of the single group(P<0.05).After treatment,the QT dispersion,QRS wave time limit change,ventricular premature contraction frequency and short array ventricular tachycardia frequency in the combined group were significantly lower than those in the single group,and the standard deviation of sinus R-R interval and the average value of adjacent sinus R-R interval were higher than those in the single group(P<0.05).After treatment,the levels of brain natriuretic peptide(BNP),cardiac troponin T(cTnT),soluble ST2 protein(sST2)and blood lactate(BLA)in the combined group were significantly lower than those in the single group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Metoprolol tartrate combined with amiodarone hydrochloride tablets in the treatment of CHD complicated with arrhythmia patients can achieve safe and efficient ideal effect.
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