Effect of endoscopic metal titanium clip combined with pantoprazole in the treatment of peptic ulcer bleeding and its influences on pepsin and platelet activation function
Objective To investigate the effect of endoscopic metal titanium clip combined with pantoprazole in the treatment of peptic ulcer bleeding and its influences on pepsin and platelet activation function.Methods A total of 120 patients with peptic ulcer bleeding admitted from January 2019 to January 2022 were selected and divided into control group(60 cases,pantoprazole treatment)and study group(60 cases,endoscopic metal titanium clip combined with pantoprazole treatment)according to the lottery method.The clinical effect,pepsin activity,platelet activation function,hemostasis time,bleeding volume and hospitalization time were compared between the two groups;the incidence of complications in the study group was statistically analyzed.Results The total effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05).After treatment,the levels of pepsinogenⅠ(PGⅠ)and pepsinogenⅡ(PGⅡ)in the study group were lower than those in the control group(P<0.05).After treatment,the levels of platelet activating factor(PAF),platelet factor 4(PF4)and β-thromboglobulin(β-TG)in the study group were higher than those in the control group(P<0.05).The hemostasis time and hospitalization time of the study group were shorter than those of the control group,and the bleeding volume was less than that of the control group(P<0.05).There were no complications in 60 patients in the study group,and the incidence of complication was 0.Conclusion Endoscopic metal titanium clip combined with pantoprazole in the treatment of patients with peptic ulcer bleeding has a significant effect,which can effectively reduce the bleeding volume,inhibit pepsin activity,and improve platelet activation function;in addition,the treatment also has the advantages of rapid hemostasis,rapid postoperative recovery and high safety,which is worthy of promotion.
万方数据
维普
