Effect of narrow-spectrum intense pulsed light combined with minocycline hydrochloride in the treatment of rosacea and its influences on IgG,IgM levels and skin barrier function
Objective To study the effect of narrow-spectrum intense pulsed light combined with minocycline hydrochloride in the treatment of rosacea and its influences on immunoglobulin G(IgG),immunoglobulin M(IgM)levels and skin barrier function.Methods A total of 120 patients with rosacea admitted in our hospital from January 2018 to January 2021 were selected and divided into control group and observation group according to different treatment methods,with 60 cases in each group.The control group was treated with minocycline hydrochloride,and the observation group was treated with narrow-spectrum intense pulsed light on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of erythema,papule pustules,telangiectasia and pruritus in the two groups significantly decreased,those in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)and procalcitonin(PCT)in the two groups significantly decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,the levels of IgG and IgM in the two groups significantly decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,the trans-epidermal water loss(TEWL)and the number of erythema in the two groups decreased,the skin water content and grease increased,those in the observation group were better than the control group,and the differences were statistically significant(P<0.05).Conclusion Narrow-spectrum intense pulsed light combined with minocycline hydrochloride is effective in the treatment of rosacea,it can alleviate the clinical symptoms of patients,reduce inflammation,and improve immune function and skin barrier function,which is worthy of clinical promotion and application.
minocycline hydrochloridenarrow-spectrum intense pulsed lightrosaceaimmunoglobulin Gimmunoglobulin Mskin barrier function
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