摘要
目的 探究甘油三脂-葡萄糖(TyG)指数与冠状动脉钙化(CAC)的关系.方法 回顾性纳入 1 572 例经冠状动脉计算机断层扫描血管造影(CTA)检查患者为研究对象,根据冠脉钙化积分(CACS)将其分为钙化组(CACS≥1 分)和无钙化组(CACS=0 分).采用多因素Logistic回归分析评估CAC发生的影响因素.结果 1 572例患者中,存在CAC的患者808例(钙化组);无CAC的患者764例(无钙化组).钙化组的男性占比、年龄、高血压史占比、糖尿病史占比、TyG指数、空腹血糖、糖化血红蛋白、血尿素氮、血肌酐、C反应蛋白水平高于无钙化组(P<0.05).Logistic回归分析显示,年龄、高血压史、糖尿病史、TyG指数、血肌酐、C-反应蛋白是CAC发生的独立危险因素(P<0.05).结论 TyG指数与CAC的发生独立相关,其对CAC的发生有较高预测价值.
Abstract
Objective To investigate the relationship between triglyceride-glucose(TyG)index and coronary artery calcification(CAC).Methods A total of 1 572 patients who underwent coronary computed tomography angiography(CTA)examination were retrospectively included in the study.According to the coronary artery calcium score(CACS),the patients were divided into calcification group(CACS≥1)and non-calcification group(CACS=0).Multivariate Logistic regression analysis was used to evaluate the influencing factors of CAC.Results Among the 1 572 patients,there were 808 patients with CAC(calcification group);there were 764 patients without CAC(non-calcification group).The proportion of males,age,proportion of hypertension history,proportion of diabetes history,TyG index,fasting blood glucose,glycosylated hemoglobin,blood urea nitrogen,serum creatinine and C-reactive protein levels in the calcification group were higher than those in the non-calcification group(P<0.05).Logistic regression analysis showed that age,hypertension history,diabetes history,TyG index,serum creatinine and C-reactive protein were independent risk factors for CAC(P<0.05).Conclusion TyG index is independently associated with the occurrence of CAC,which has a high predictive value for the occurrence of CAC.
基金项目
苏州市科技计划(SLJ2022007)
苏州市基础研究计划(医学应用基础研究)项目(2023)(SKYD2023084)
NETL
NSTL
万方数据