Effects of transcranial magnetic stimulation combined with levetiracetam tablets and carbamazepine tablets respectively in the treatment of epilepsy and its influences on serum Nesfatin-1,S100B and BDNF levels
Objective To investigate the effects of transcranial magnetic stimulation combined with levetiracetam tablets and carbamazepine tablets respectively in the treatment of epilepsy and its influences on serum Nesfatin-1,S100 calcium binding protein B(S100B)and brain-derived neurotrophic factor(BDNF)levels.Methods A total of 80 patients with epilepsy who were treated from February 2018 to February 2022 were divided into study group(n=40)and control group(n=40)according to the random number table method.Both groups were treated with transcranial magnetic stimulation.On this basis,the study group was treated with levetiracetam tablets,and the control group was treated with carbamazepine tablets.The clinical effects of the two groups were compared.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).After treatment,the cognitive function score of the two groups increased,and that of the study group was higher than the control group(P<0.05).After treatment,the levels of Nesfatin-1 and S100B in the two groups decreased,the level of BDNF increased,and those in the study group were better than the control group(P<0.05).After treatment,the scores of each dimension of Quality of Life in Epilepsy-31(QOLIE-31)in the two groups increased,and those in the study group were higher than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The transcranial magnetic stimulation combined with levetiracetam tablets in the treatment of epilepsy has significant effect,which can improve the cognitive function,promote the decrease of serum Nesfatin-1 and S100B levels and the increase of BDNF level,and has high safety.
transcranial magnetic stimulationepilepsylevetiracetam tabletscarbamazepine tablets